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Amsphere™ A3 is a next generation Protein A chromatography resin for advanced protein separation in downstream processing of therapeutic antibodies manufacturing.


Current A3 Programs 


Phase I


Phase II


Phase III

Commercial Programs  1

How Can Amsphere™ A3 Help Me?

Besides an outstanding high capacity, Amsphere™ A3 has an overall improved process robustness, flow characteristics, optimized impurity removal, productivity and resin lifetime.

JSR Life Sciences Amsphere Bead with Antibodies


Protein A Ligand
High DBC via controlled conformation and orientation
High alkaline stability from protein engineering
Surface modification
Low HCP levels by surface hydrophilization
Base bead formulation
High DBC at high flow rate
Good pressure and flow properties via rigid crosslinking


Catalog Numbers & Product Sizes

  • North America, EMEA & APAC Regions


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Why use Amsphere™ A3?


Why Amsphere A3 is an Outstanding Choice for Antibody Fragment & FC-Fusion Purification

Universal Affinity Resin for
Non-classical mAbs

Simplify Your Supply Chain
& Minimize Costs

Impurity Clearance

Learn More

Untitled design (47)

Presenter: Beatriz Catalao
Application Engineer, JSR Life Sciences

JSR LS White Horizontal Logo 2019OCT62019 (1)


OnDemand Webinar

Packing of Protein A resins in lab-, pilot-and large-scale columns: How to achieve a "right first time"- PART 1


This video webinar, presented by Beatriz Catalao of JSR Life Sciences, is on the topic of column packing of protein A resins in lab, pilot, and large-scale columns. Beatriz provides a quick introduction to Amsphere A3, a protein A resin, and highlights the column packing preparation requirements to achieve a successfully packed bed.

Beatriz also mentions the high binding capacity, alkali stability, and impurity removal capabilities of Amsphere A3, emphasizing its added value for default batch and next-generation intensified bioprocessing.  Additionally, Beatriz mentions the availability of regional application support, on-site packing support, packing training, and experimental support.

Throughout the webinar, various methods and factors for determining slurry concentration and compression factor are explained, along with guidelines for selecting the right column and bed supports.  The video also discusses the recommended compression factors for different column diameter ranges and provides flow rate ranges for different column sizes.  Finally, it presents guidelines for resin slurry handling and discusses suitable and unsuitable pump options for transferring the slurry.

This is part one of a webinar series and focuses on the column packing process preparations, with a second webinar planned to cover column packing and evaluation.



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