Amsphere A3 Logo RGB 2021NOV23

Amsphere™ A3 is a next generation Protein A chromatography resin for advanced protein separation in downstream processing of therapeutic antibodies manufacturing.


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Current A3 Programs 


Phase I


Phase II


Phase III



Commercial Programs  1

Catalog Numbers & Product Sizes

  • North America, EMEA & APAC Regions


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Why use Amsphere™ A3?


Why Amsphere A3 is an Outstanding Choice for Antibody Fragment & FC-Fusion Purification

Universal Affinity Resin for
Non-classical mAbs

Simplify Your Supply Chain
& Minimize Costs

Impurity Clearance

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Development of effective purification process for bispecifics using affinity capture and mix-mode polishing chromatography

KBI Biopharma and JSR Life Sciences have developed processes for the purification of BsAbs utilizing Amsphere A3 affinity chromatography followed by two polishing steps to eliminate undesirable homodimers and other impurities.

Amsphere A3’s superior binding capacity, resin lifetime, and caustic stability can provide a cost effective, supply-chain stable purification strategy when paired with well-designed polishing steps. In addition to A3 affinity capture, KBI’s platform BsAb purification process includes mixed-mode anion exchange and cation exchange to eliminate homodimeric impurities.

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Presenter: Hunter Reese Ph.D.
Scientist, KBI Biopharma Inc.

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