Chromassette® is a stackable, pre-packed chromatography cassette with an internal lattice that supports the resin bed. It combines the separation capabilities of conventional chromatography resins with the benefits of a pre-packed, modular cassette format. The supported bed within the Chromassette device allows high flow rates to be used with all standard chromatography resins, including legacy and other “mechanically soft” resins which otherwise offer good capacity and selectivity. This enables up to 10-fold productivity improvements. In addition,
Chromassette devices allow flexible scaling to conveniently and easily meet process capacity requirements. Standard cassettes are available at bed heights of 20 and 6 cm. While 20 cm bed height is often considered a benchmark value for Protein A chromatography columns, shorter bed heights allow for even greater increases in productivity and throughput. Chromassette also allows for easy scale-up of these short bed height cassettes, while large scale columns with short bed heights are very challenging to pack.
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