Currently under development, Chromassette® is an innovative chromatography platform that can help improve the operational efficiency and productivity of your purification processes.
Chromassette’s unique internal scaffold enables high flow-rates for any resin and its modularity allows for linear scalability.
Unlike column chromatography with a limited number of sizes and a loss of wall support as the column is scaled-up, Chromassette’s lattice is highly supportive of the resin beads and comes in an easy-to-stack, pre-packed, disposable cassette format.
As a result, your process will be easier to set up, scale up and speed up.
With Chromassette, chromatography packaged in a cassette, you can achieve a highly productive and fully disposable process that scales to any volume with any resin.
With a traditional column, resin compression exists since wall support decreases as the column diameter increases. With Chromassette, compression is drastically minimized since all resin beads benefit from constant wall support.
The normalized pressure gradient for a column increases exponentially as flow-rate is increased. However, a linear relationship is maintained for Chromassette regardless of the scale or resin bead size utilized. High flow-rates, and ultimately high productivity, is obtainable with Chromassette.
Chromassette is designed for easy stacking, storage and configuration, resulting in an increase in operational efficiency and flexibility, thereby avoiding column packings, maintenance, and large footprints for column processing and storage.
In traditional columns, a nonlinear increase in column volume from one diameter size to another is observed since only a limited number of column diameters are offered by manufacturers. Given that each Chromassette cassette is constant in size, each stacked cassette leads to a linear increase in resin volume with no change to overall pressure/flow profiles. Matching resin volume to protein load volume has never been easier.
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