A next generation, high capacity protein A chromatography resin for advanced protein separation in downstream processing.
Amsphere A3 is a next generation Protein A chromatography resin for advanced protein separation in downstream processing of therapeutic antibodies manufacturing.
Besides an outstanding high capacity, Amsphere A3 has an overall improved process robustness, flow characteristics, optimized impurity removal, productivity and resin lifetime.
KBI Biopharma and JSR Life Sciences have developed processes for the purification of BsAbs utilizing Amsphere A3 affinity chromatography followed by two polishing steps to eliminate undesirable homodimers and other impurities.
Amsphere A3’s superior binding capacity, resin lifetime, and caustic stability can provide a cost effective, supply-chain stable purification strategy when paired with well-designed polishing steps. In addition to A3 affinity capture, KBI’s platform BsAb purification process includes mixed-mode anion exchange and cation exchange to eliminate homodimeric impurities.