Amsphere A3
A next generation, high capacity protein A chromatography resin for advanced protein separation in downstream processing.
Amsphere A3 is a next generation Protein A chromatography resin for advanced protein separation in downstream processing of therapeutic antibodies manufacturing.
Besides an outstanding high capacity, Amsphere A3 has an overall improved process robustness, flow characteristics, optimized impurity removal, productivity and resin lifetime.
Presenter: Gerald Platteau
Senior Application Engineer
JSR Life Sciences
This webinar will discuss the efficacy of cleaning off proteinaceous fouling from a methacrylate-based Protein A resin for an extensive range of CIP protocols. Furthermore, an in-depth statistical analysis is presented on the cleaning effects of both NaOH concentration and contact time. Together with the impact on DBC retention, this can assist process engineers in developing intensified cleaning strategies. Finally, guidelines are presented for using peracetic acid to sanitize the resin in the event of contamination with spore-forming bacteria.