Protein A based affinity chromatography is built into many downstream bioprocess platforms as an affinity capture step for GMP-certified biotechnology manufacturers’ monoclonal antibodies (mAbs) and mAb-related molecules such as Fc fusion proteins and antibody fragments. Along with being a workhorse for mAb capture, plus protein and nucleic acid contaminant removal, Protein A chromatography is capable of reducing the amounts of viral contaminants and can be utilized in downstream purification to support viral clearance for GMP manufacturing.
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