Sodium hydroxide (NaOH) is most commonly used for cleaning in place (CIP) of Protein A media and caustic stability is therefore an important asset.
During its whole lifetime, performance of the resin needs to remain within set specifications. In view of cost benefits, resin lifetime in number of cycles should be as long as possible and will depend on operating conditions, e.g. the sodium hydroxide concentration and contact time.
We have investigated the stability of Amsphere A3 when using 15 minutes of contact time with 0.5 M NaOH as CIP step.
Enter your information below and receive the application note instantly.