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Learn More About Protein A Resin: An Optimized Media to Minimize The Impact of Elution Buffer Selection

Protein A chromatography is widely used as the affinity capture step of both mAbs and Fc-fusion proteins because of its high degree of selectivity. Variations in elution behavior of the protein A capture step require more process development work and could have an impact on the polishing step in the downstream process. Thus, minimizing the variation in elution pH between different molecules for example, makes it easier to platform the capture process.

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