Fc-fusion proteins are immunoglobin Fc domains linked to proteins with therapeutic potential. These can favorably increase serum half-life and alter a biopharmaceutical’s immunological properties. There are currently 13 commercially approved Fc-fusion biopharmaceuticals and many more in clinical trials (1, 2). Capture chromatography of Fc-fusion proteins on Protein-A based affinity chromatography resins is a favored method of purification.
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